Israel expressed concern about the possibility of the US administration's retreat from its stance toward Iran, following the second round of indirect talks between US and Iranian officials in Rome, which concluded with an agreement to begin developing a framework for a potential nuclear agreement.

The Sultanate of Oman, which is mediating between the two countries, announced that the talks aim to reach a binding agreement that guarantees Iran's complete denuclearization and the lifting of sanctions, while preserving its ability to develop peaceful nuclear energy.

Israeli Prime Minister Benjamin Netanyahu said in his speech hours after the conclusion of US-Iranian talks that he is "committed" to preventing Iran from possessing nuclear weapons.

The Israel Hayom website reported, citing a source close to the White House, that talks between the United States and Iran are expected to collapse soon. A non-governmental Israeli source said he had a conversation with a senior US official, during which the latter confirmed that "Israel has no reason to be concerned about the progress made in the talks with Iran." According to the US official, the negotiations will likely collapse once Washington presents its full list of demands. The source added that the conversation focused on the ongoing talks between US envoy Steve Witkoff and Iranian representatives regarding Iran's nuclear program, reiterating that Israel has no need to fear these developments.

The Israeli source, citing a US official, said that President Trump "is fully aware of the Iranian threat and is handling the negotiations in his own way." The Israeli official predicted that "the talks with Iran will collapse within weeks once Washington presents its full demands, which include dismantling the nuclear program based on the Libyan model, halting the development of ballistic missiles, and ending the activities of Iranian proxies in the Middle East."

The source added, "We must leave Trump free rein. He knows what he's doing." He emphasized that the United States has not given up on the basic demands set by the Trump administration.

Israel insists that any negotiations with Iran must lead to the complete dismantling of its nuclear program.

This came as Reuters reported, citing an Israeli official and two informed sources, that Israel does not rule out launching an attack on Iranian nuclear facilities in the coming months, despite US President Donald Trump informing Netanyahu that the United States is not currently prepared to support such a move.

Over the past several months, Israel has proposed a series of options to the Trump administration for attacking Iranian facilities, some of which are planned for late spring and summer, according to the sources. The sources say the plans include a combination of airstrikes and special forces operations of varying intensity, and would likely hinder Tehran's ability to use its nuclear program for military purposes for months, a year, or more. The New York Times reported on Wednesday that Trump told Netanyahu in a White House meeting earlier this month that Washington wanted to prioritize diplomatic talks with Tehran and that he was not prepared to support a strike on Iranian nuclear facilities in the short term.

Israeli Foreign Minister Gideon Sa'ar denied reports that Trump intervened to stop an Israeli operation against Iranian nuclear facilities.

"I am a member of the Security Council and all the sensitive forums, and I don't recall such a decision being taken. I don't think such a decision was ever taken," Sa'ar told the British newspaper The Daily Telegraph. "But Israel is committed to preventing Iran from acquiring a nuclear weapon. If this goal can be achieved diplomatically, we accept it."

Sa'ar expressed concern about the possibility of the next US administration weakening its resolve toward Iran, but pointed to a post by US negotiator Steve Witkoff on the X platform last week, in which he emphasized his desire to dismantle the Iranian nuclear program, both in terms of enrichment and weapons.

Sa'ar said, "I believe the current administration is committed to dealing with this issue and has made it a priority. More important than that is the goal: Iran must not possess a nuclear weapon."

He added, "We have seen how Iran assisted Russia during its war in Ukraine, with weapons, drones, and intelligence," warning of "the great danger of enabling the world's most extremist regimes to possess the world's most dangerous weapons." He emphasized that Iranian missiles are already capable of reaching Europe.

Sa'ar warned of nuclear proliferation in the region if Iran acquires a nuclear weapon, saying: "A nuclear arms race will begin in the Middle East... and this will have serious repercussions for security, not just in the region, but in the world."

He continued: "Iran has attacked Israel twice with hundreds of missiles, and uses proxies like Hezbollah, Hamas, and the Houthis to destabilize the entire Middle East. If it did all this without a nuclear umbrella, what could it do if it obtained a nuclear umbrella?"

The Israeli minister concluded by warning that Iran is not fulfilling its international obligations: "Iran has always flouting its commitments. I don't rule out the possibility that it will seek partial agreements to avoid a radical solution. We are speaking directly with the Americans, as well as with our European friends. Iran is currently in a position of relative weakness, and this must be exploited to achieve the goal, not given a reprieve until circumstances change."

Israel's Channel 14 reported that "the new agreement being negotiated may be better for the Iranians than the one signed during the Obama era, despite Trump's declaration of a tough stance toward Tehran." It added, "Sanctions are expected to be lifted, billions will be pumped in, and terrorist arms, from Hamas to the Houthis, will return to activity. Moreover, Iran's proxies are still active in Iraq, Yemen, and even Africa, indicating that the danger has not disappeared, but is on the rise again... Experts are arriving, equipment is being smuggled in, and the money is still there. Not in the quantities it was in the past, but it is completely enough to keep the system alive and breathing."

She added, "The agreement demonstrates the contours of Obama's policy, despite Trump's rhetoric, and raises security concerns for Israel, which appears isolated in the confrontation."

For its part, Israel's Channel 13 reported that "the Israeli leadership is monitoring developments in the negotiations and is pressuring Washington not to sign an agreement that would allow Iran to acquire nuclear capabilities, even if they are civilian." It added, "Many Israeli officials want these talks to fail, or for them to be accompanied by an American threat to use force."